1: Introduction
Many of the research articles that we discuss use functional magnetic resonance imaging (fMRI) as a means to indirectly measure changes in brain activity and brain structure. To better acquaint ourselves with basic brain anatomy and brain systems that are involved in mental illness and recovery, we held an initial introductory session on March 4, 2008. The powerpoint presentation can be viewed or downloaded although many of the embedded movie clips will not display. To learn more about basic brain anatomy and fMRI, please visit links for Brain Voyager and the free downloadable BV Tutor. One of the basic brain systems we discussed briefly was the frontal cortex. We used the Stroop Task as an example of what it feels like to use this brain region. Another brain region we discussed briefly was the amygdala. In both cases, we discussed developmental work by Dr. David Lewis on the development of the frontal cortex in schizophrenia. We also discussed the work of Dr. Bruce McEwen on how stress can influence the function of emotional regulatory systems containing the amygdala. Lastly, we reviewed a paper by Dr. Helen Mayberg entitled, "Modulation of Cortical-Limbic Pathways in Major Depression" that finds that cognitive and behvioral interventions can influence the function of the frontal cortex in a way that is different than medication therapy alone. You can also click here to hear a podcast on the rehabilitation of treatment resistant depression by Dr. Mayberg. The main take home message from session 1 was that there are many brain systems involved in mental illness but many are well characterized in terms of structure and connectivity.
Comments, suggestions and questions are most welcome !
Bridgeway Rehabilitative Services sponsors this discussion in a continuing education effort and ongoing program to remove stigma from mental illness. We are grateful for support from The Center for the Study and Promotion of Recovery from Severe Mental Illness and the Merck Company Foundation.